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A Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis


Supported by Patient Centered Outcomes Research Institute Award (1409-240099).

Disclosure forms The full text of this article is available on NEJM.org provided by the authors.

Dr. Evans reports receiving advisory board fees from Tetrapage Pharmaceuticals; Dr. Grants from Moran, Allergan, ContraFect, and Nabriva are receiving support; Receiving grant support from Dr. Park, Bristol Myers Squibb and Atox Bio; And Dr. Vinchal is receiving consulting fees from the striker. No other potential conflict of interest relevant to this article was stated.

Members of the writing committee are: David R. Flum, MD, MPH, Gina H. Davidson, MD, MPH, Sarah E. Moncel, MS, Nathan I. Shapiro, MD, MPH, Stephen R. Odom, MD, Sabrina E. Sanchez, MD, MPH, F Thurston Drake, MD, MPH, Katherine Fiskoff, MD, Jeffrey Johnson, MD, Joe H. Patton, MD, Heath Evans, MD, Joseph Cusieri, MD, Amber Kay. Sabbatini, MD, MPH, Brett A. Fine, Pharma., Dion a. Skeet, MD, Mike K. Liang, MD, Vance Sohn, MD, Karen McGrann, MD, Matthew E. Kachar, MD, Bruce Chung, MD, Damian W. Carter, MD, Patricia Ayong-chi, MD, MPH, William Chiang, MD, Amy Rushing, MD, Steven Steinberg, MD, Karen S. Foster, MD, Shaina M. Gatchel, MD, Thea P. Price, MD, Catherine A. Mandel, MD, MPH, Lisa Ferigno, MD, MPH, Matthew Salzburg, MD, Daniel A. Deggart, MD, Amy H. Kazi, MD, PhD, Greg J. Moran, MD, MD Darin Saltzman, MD, PhD, Hassan b. Alam, MD, Pauline K. Park, MD, Lillian S. Cao, MD, Callie M. Thompson, MD, Wesley H. Sw., MD, MPH, Juliana T. Yu, MD, Abigail Wiebusch, MD, Robert J. Winchell, MD, Sunday Clark, Sc.D., MPH, Anusha Krishnadasan, Ph.D., Erin Fannon, BA, Danielle C. Lavallee, Pharm.D., Ph. .D., Bryan A. Comstock, MS, Bonnie Biesel, M.Ed., Patrick J. Hegarty, PhD, Larry G. Kessler, Scad, and David A. Talan, MD.

The CODA Collaborative Writing Committee assumes responsibility for the content of this article. The ideas presented in this work are solely the responsibility of the authors and do not necessarily represent the views of the Patient-Centered Outcomes Research Institute, its board of governors, or its methodology committee.

This article was published on October 5, 2020 on NEJM.org.

a Data sharing statement The full text of this article is available at NEJM.org provided by the authors.

We thank Margo Goderski and Caroline Chevrin, MS, for their outstanding efforts in coordinating the initial publication of the test results; Many surgeons, emergency department physicians, and research staff members who helped make this test a success; And all test participants for their generosity and altruism.



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